Chemical Structure : UNC9426
CAS No.:
3051784-94-9
UNC9426
(UNC 9426, UNC-9426)
Catalog No.: PC-24218Not For Human Use, Lab Use Only.
UNC9426 is a potent, specific TYRO3 inhibitor with IC50 of 2.1 nM, has 276- and 90-fold selectivity over MERTK and AXL respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UNC9426 is a potent, specific TYRO3 inhibitor with IC50 of 2.1 nM, has 276- and 90-fold selectivity over MERTK and AXL respectively.
UNC9426 is highly selective and TYRO3 is the only kinase that was completely inhibited at 1 uM agianst a 77-kinase panel.
UNC9426 binds tightly to TYRO3 with an EC50 of 89.8 nM in NanoBRET assays, no obvious binding to MERTK or AXL (EC50>10 uM).
UNC9426 inhibits human platelet aggregation, reduces the expression of human platelet surface activation markers, without increasing bleeding time and blocked TYRO3-dependent functions in tumor cells and macrophages.
Physicochemical Properties
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M.Wt
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632.66
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Formula
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C32H34F6N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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trans-4-(2-((3,5-Bis(trifluoromethyl)phenyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol
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References
1. Kong D, et al. J Med Chem. 2025 Mar 11. doi: 10.1021/acs.jmedchem.5c00048.
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