UPF-1069 is a potent, selective PARP-2 inhibitor with IC50 of 0.3 uM, >25-fold selective over PARP-1 (IC50= 8 uM). UPF-1069 does not interact with other PARP family member enzymes (including tankyrase-1). UPF-1069 reduced post-ischaemic damage at both low and high concentrations in mixed cortical cells exposed to oxygen-glucose deprivation (OGD). UPF-1069 exacerbates OGD toxicity in hippocampal CA1 pyramids and reduces it in cortical neurons.
Physicochemical Properties
M.Wt
279.30
Formula
C17H13NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one
References
1. Moroni F, et al. Br J Pharmacol. 2009 Jul;157(5):854-62.
2. Pellicciari R, et al. ChemMedChem. 2008;3:914–923.
