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UPF1854

Chemical Structure : UPF1854

CAS No.: 1569869-46-0

UPF1854 (UPF 1854;UPF-1854)

Catalog No.: PC-63335Not For Human Use, Lab Use Only.

UPF1854 is a potent tankyrase inhibitor with IC50 of 12 nM and 200 nM for TNKS1 and TNKS-2 respectively, displays no cross-reactivity versus other PARP proteins.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UPF1854 is a potent tankyrase inhibitor with IC50 of 12 nM and 200 nM for TNKS1 and TNKS-2 respectively, displays no cross-reactivity versus other PARP proteins.
    UPF1854 displays good long-term growth inhibition in DLD-1 cancer cells.

    Physicochemical Properties

    M.Wt 269.308
    Formula C14H15N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-[2-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-ylamino)-ethyl]-phenol

    References

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