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Chemical Structure : UR-1102
Catalog No.: PC-60708Not For Human Use, Lab Use Only.
UR-1102 is a novel potent and selective, orally active URAT1 inhibitor with Ki of 57 nM, 130 and 42-fold selectivity over OAT1 and OAT3, respectively.
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UR-1102 is a novel potent and selective, orally active URAT1 inhibitor with Ki of 57 nM, 130 and 42-fold selectivity over OAT1 and OAT3, respectively.
UR-1102 increases the fractional excretion of urinary uric acid, and reduces plasma uric acid more effectively in vivo, compared with benzbromarone.
UR-1102 also shows lower in vitro potential for mechanisms causing the hepatotoxicity induced by benzbromarone.
| M.Wt | 414.053 | |
| Formula | C14H10Br2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ahn SO, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):157-66.
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