Catalog No.: PC-60708Not For Human Use, Lab Use Only.
Epaminurad (UR-1102) is a novel potent and selective, orally active URAT1 inhibitor with Ki of 57 nM, 130 and 42-fold selectivity over OAT1 and OAT3, respectively.
Epaminurad (UR-1102) is a novel potent and selective, orally active URAT1 inhibitor with Ki of 57 nM, 130 and 42-fold selectivity over OAT1 and OAT3, respectively.
UR-1102 increases the fractional excretion of urinary uric acid, and reduces plasma uric acid more effectively in vivo, compared with benzbromarone.
UR-1102 also shows lower in vitro potential for mechanisms causing the hepatotoxicity induced by benzbromarone.
