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UR-Po563

Chemical Structure : UR-Po563

CAS No.: 3034046-79-9

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UR-Po563 (UR-Po 563)

Catalog No.: PC-49736Not For Human Use, Lab Use Only.

UR-Po563 is a potent, selective H2 receptor agonist with pKi of 7.75, >400-fold selectivity over H1R/H3R/H4R.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UR-Po563 is a potent, selective H2 receptor agonist with pKi of 7.75, >400-fold selectivity over H1R/H3R/H4R.
    UR-Po563 increased force of contraction in left atrium from H2-TG mice with pEC50 values of 8.27.
    UR-Po563 increased force of contraction in isolated human right atrial muscle strips.

    Physicochemical Properties

    M.Wt 360.48
    Formula C17H24N6OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Urea, N-[[[3-(2-amino-4-methyl-5-thiazolyl)propyl]amino]iminomethyl]-N′-[(1R)-1-phenylethyl]-

    References

    1. Ulrich Gergs, et al. J Pharmacol Exp Ther. 2021 Nov;379(3):223-234.

    2. Biselli S, et al. Eur J Med Chem 214:113190

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