Chemical Structure : URAT1 inhibitor TD-3
CAS No.:
2803951-18-8
URAT1 inhibitor TD-3
Catalog No.: PC-24745Not For Human Use, Lab Use Only.
URAT1 inhibitor TD-3 is a potent, selective inhibitor of urate transporter 1 (URAT1), inhibits URAT1-mediated 14C-UA uptake with IC50 of 1.36 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
URAT1 inhibitor TD-3 is a potent, selective inhibitor of urate transporter 1 (URAT1), inhibits URAT1-mediated 14C-UA uptake with IC50 of 1.36 uM.
TD-3 shows favorable safety profiles, and no obvious acute toxicity was observed in Kunming mice under a single dose of 1000 mg/kg.
TD-3 has excellent ability to lower serum urate in vivo.
TD-3 has avorable safety and pharmacokinetic properties, oral bioavailability, and potent in vitro inhibition (IC50 1.36 µM), surpassing lesinurad in all aspects.
Physicochemical Properties
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M.Wt
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456.36
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Formula
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C21H18BrN3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((1-((4-Bromonaphthalen-1-yl)methyl)-1H-imidazo[4,5-b]pyridin-2-yl)thio)-2-methylpropanoic Acid
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References
1. Suo Y, et al. Nat Commun. 2025 Jun 4;16(1):5178.
2. Tong Zhao, et al. J Med Chem. 2022 Mar 10;65(5):4218-4237.
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