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Chemical Structure : URB602
CAS No.: 565460-15-3
Catalog No.: PC-42260Not For Human Use, Lab Use Only.
URB602 is a selective, noncompetitive monoacylglycerol lipase (MAGL) inhibitor with IC50 of 28 uM against rat brain MAGL.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $198 | In stock | |
| 250 mg | Get quote |
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URB602 is a selective, noncompetitive monoacylglycerol lipase (MAGL) inhibitor with IC50 of 28 uM against rat brain MAGL.
URB602 elevates 2-AG levels and enhances 2-AG-mediated signaling in neurons, prolongs endocannabinoid-mediated changes in synaptic strength in acutely dissected rat hippocampal slices.
URB602 showed anti-inflammatory and anti-nociceptive effect in murine model of acute inflammation.
| M.Wt | 295.3755 | |
| Formula | C19H21NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Carbamic acid, N-[1,1'-biphenyl]-3-yl-, cyclohexyl ester |
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1. Hohmann AG, et al. Nature. 2005 Jun 23;435(7045):1108-12.
2. King AR, et al. Chem Biol. 2007 Dec;14(12):1357-65.
3. Makara JK, et al. Nat Neurosci. 2005 Sep;8(9):1139-41.
4. Comelli F, et al. Br J Pharmacol. 2007 Nov;152(5):787-94.
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