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URB602

Chemical Structure : URB602

CAS No.: 565460-15-3

URB602 (URB 602, URB-602)

Catalog No.: PC-42260Not For Human Use, Lab Use Only.

URB602 is a selective, noncompetitive monoacylglycerol lipase (MAGL) inhibitor with IC50 of 28 uM against rat brain MAGL.

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Biological Activity

URB602 is a selective, noncompetitive monoacylglycerol lipase (MAGL) inhibitor with IC50 of 28 uM against rat brain MAGL.
URB602 elevates 2-AG levels and enhances 2-AG-mediated signaling in neurons, prolongs endocannabinoid-mediated changes in synaptic strength in acutely dissected rat hippocampal slices.
URB602 showed anti-inflammatory and anti-nociceptive effect in murine model of acute inflammation.

Physicochemical Properties

M.Wt 295.3755
Formula C19H21NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Carbamic acid, N-[1,1'-biphenyl]-3-yl-, cyclohexyl ester

References

1. Hohmann AG, et al. Nature. 2005 Jun 23;435(7045):1108-12.

2. King AR, et al. Chem Biol. 2007 Dec;14(12):1357-65.

3. Makara JK, et al. Nat Neurosci. 2005 Sep;8(9):1139-41.

4. Comelli F, et al. Br J Pharmacol. 2007 Nov;152(5):787-94.

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