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Chemical Structure : USC-373
Catalog No.: PC-72670Not For Human Use, Lab Use Only.
USC-373 is a phosphonate prodrug of HPMPC (cidofovir) with activity against VZV and other DNA viruses.
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USC-373 is a phosphonate prodrug of HPMPC (cidofovir) with activity against VZV and other DNA viruses.
USC-373 is potent against VZV Ellen laboratory strain and is not overtly toxic, with EC50 of 4 nM and CC50 of 0.2 uM.
USC-373 is effective against VZV-ORF57-Luc wild type strain and the acyclovir-resistant isogenic strain in ARPE-19 cells.
USC-373 prevents VZV spread and is well-tolerated in vivo when administered orally.
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