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USP39_PROTAC_V1

Chemical Structure : USP39_PROTAC_V1

CAS No.:

USP39_PROTAC_V1 (USP39 PROTAC V1)

Catalog No.: PC-26238Not For Human Use, Lab Use Only.

USP39_PROTAC_V1 is a potent, selective VHL‐based PROTAC degrader of USP39 with KD of 232 nM, DC50 of 1 nM in HeLa cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

USP39_PROTAC_V1 is a potent, selective VHL‐based PROTAC degrader of USP39 with KD of 232 nM, DC50 of 1 nM in HeLa cells.

Physicochemical Properties

M.Wt 870.48
Formula C41H52ClN7O8S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((4-chlorophenyl)amino)-N-((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)thiazole-4-carboxamide

References

1. Schäfer D, et al. Angew Chem Int Ed Engl. 2026 Jan 28;65(5):e16809.

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