Catalog No.: PC-20720Not For Human Use, Lab Use Only.
UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively.
UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively.
Treatment with UT-11 (10 mg/kg) significantly blunted the upregulation of mPGES-1 induced by LPS in the hippocampus.
UT-11 also blunted thte upregulation of other inflammatory genes (IL-6, TNF-α, CCL2, CCL3, CCL4) in the hippocampus in mice.
