UTBinh-14 (UT-B-IN-1)

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Chemical Structure : UTBinh-14

Catalog No.: PC-21373Not For Human Use, Lab Use Only.

UTBinh-14 (UT-B-IN-1) is a potent, highly selective inhibitor for urea transporter UT-B with IC50 of 11 nM, with over a thousand-fold selectivity over UT-A.

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Biological Activity

UTBinh-14 (UT-B-IN-1) is a potent, highly selective inhibitor for urea transporter UT-B with IC50 of 11 nM, with over a thousand-fold selectivity over UT-A.
UTBinh-14 selectively and reversibly inhibited urea transport with IC50 of 25.1 nM and reduced urinary concentration in mice.

Physicochemical Properties

M.Wt	455.57
Formula	C20H17N5O2S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-ethylphenyl)sulfonyl)-N-(thiophen-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

References

1. M. O. Anderson, et al. J. Med. Chem. 55, 5942–5950 (2012).

2. Chi G, et al. Sci Adv. 2023 Sep 29;9(39):eadg8229.

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UTBinh-14 (UT-B-IN-1)

Biological Activity

Physicochemical Properties

References

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