UTKO1

Chemical Structure : UTKO1

Catalog No.: PC-23288Not For Human Use, Lab Use Only.

UTKO1 is a cell migration inhibitor targeting 14-3-3ζ, also is a selective small molecule inhibitor of notochord tubulogenesis, binds directly and selectively to Ciona 14-3-3εa.

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Biological Activity

UTKO1 is a cell migration inhibitor targeting 14-3-3ζ, also is a selective small molecule inhibitor of notochord tubulogenesis, binds directly and selectively to Ciona 14-3-3εa.
UTKO1 inhibits 14-3-3εa interacting and colocalizing with its binding partner ezrin/radixin/moesin (ERM).
UTKO1 inhibits tumor cell migration by targeting 14-3-3ζ.
UTKO1 inhibits the second EGF-induced wave of Rac1 activation.

Physicochemical Properties

M.Wt	374.52
Formula	C23H34O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-dihydroxy-3-(2-hydroxy-3-methylene-5-(2,2,6-trimethylcyclohexyl)pentyl)-6-methylbenzaldehyde

References

1. Mizotani Y, et al. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8873-E8881.

2. Sawada M, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1385-9.

3. Kobayashi H, et al. J Biol Chem. 2011 Nov 11;286(45):39259-68.

UTKO1

Biological Activity

Physicochemical Properties

References

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