UTX-143 | NHE5 inhibitor | Probechem Biochemicals

Chemical Structure : UTX-143

UTX-143 (UTX143)

Catalog No.: PC-21711Not For Human Use, Lab Use Only.

UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1.

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Biological Activity

UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1.
UTX-143 shows potent cytotoxic activity against HT-1080 cells (IC50=15.4 uM), with no cytotoxic activity against normal cells at up to 100 μM.
UTX-143 also shows broad cytotoxic activity against esophageal squamous cell carcinoma and gastric cancer cell lines in WST-8 assays.
UTX-143 (20 uM) suppresses MMP-9 expression and MMP-2 activation in mouse metastatic melanoma cells.
UTX-143 (25 uM) has a strong invasion-inhibiting effect on HT-1080 cells.

Physicochemical Properties

M.Wt	343.39
Formula	C16H21N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-carbamimidoyl-5-((2-hydroxyethyl)(methyl)amino)-6-(p-tolyl)pyrazine-2-carboxamide

References

1. Yusei Shinohara, et al. Bioorg Med Chem. 2024 Jan 14:99:117603.

UTX-143 (UTX143)

Biological Activity

Physicochemical Properties

References

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