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UW-MD-95

Chemical Structure : UW-MD-95

CAS No.: 1393714-22-1

UW-MD-95

Catalog No.: PC-22544Not For Human Use, Lab Use Only.

UW‐MD‐95 is a potent pseudo‐irreversible butyrylcholinesterase (BChE) inhibitor with IC50 of 60 nM, does not inhibit AChE, shows potent neuroprotective in the Aβ25‐35 model of AD.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UW‐MD‐95 is a potent pseudo‐irreversible butyrylcholinesterase (BChE) inhibitor with IC50 of 60 nM, does not inhibit AChE, shows potent neuroprotective in the Aβ25‐35 model of AD.

Physicochemical Properties

M.Wt 407.56
Formula C25H33N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl heptylcarbamate

References

1. Allison Carles, et al. CNS Neurosci Ther. 2024 Jun;30(6):e14814.

2. Darras FH, et al. ACS Med Chem Lett. 2012;3:914‐919.

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