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Ubrogepant

Chemical Structure : Ubrogepant

CAS No.: 1374248-77-7

Ubrogepant (MK-1602;MK1602)

Catalog No.: PC-35253Not For Human Use, Lab Use Only.

Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine..

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Biological Activity

Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine.

Migraine

Phase 3 Clinical

Physicochemical Properties

M.Wt 549.554
Formula C29H26F3N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3'S)-1',2',5,7-Tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl]-2'-oxospiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide

References

1. Li CC, et al. J Clin Pharmacol. 2017 Nov 14. doi: 10.1002/jcph.1021.

2. Holland PR, et al. Neurotherapeutics. 2018 Apr;15(2):304-312.

3. Voss T, et al. Cephalalgia. 2016 Aug;36(9):887-98.

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