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Chemical Structure : Umeclidinium bromide
CAS No.: 869113-09-7
Catalog No.: PC-42894Not For Human Use, Lab Use Only.
Umeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $165 | In stock | |
| 25 mg | $395 | In stock | |
| 100 mg | $735 | In stock | |
| 500 mg | Get quote |
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Umeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs; demonstrates picomolar potency (-log pA2=23.9 pM) in an acetylcholine-mediated Ca(2+) mobilization assay in CHO cells transfected M3 mAChRs; dose dependently blocks Ach-induced bronchoconstriction with long duration of action in mice model of pulmonary diseases.
COPD
Approved
| M.Wt | 508.4897 | |
| Formula | C29H34BrNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
1-Azoniabicyclo[2.2.2]octane, 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-, bromide (1:1) |
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1. Salmon M, et al. J Pharmacol Exp Ther. 2013 May;345(2):260-70.
2. Tal-Singer R, et al. Eur J Pharmacol. 2013 Feb 15;701(1-3):40-8.
3. Decramer M, et al. Respir Physiol Neurobiol. 2013 Jan 15;185(2):393-9.
4. Decramer M, et al. Lancet Respir Med. 2014 Jun;2(6):472-86.
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