Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Beta-secretase (BACE)-Umibecestat
Umibecestat

Chemical Structure : Umibecestat

CAS No.: 1387560-01-1

Umibecestat (CNP520, CNP-520)

Catalog No.: PC-60085Not For Human Use, Lab Use Only.

Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.

Packing Price Stock Quantity
5 mg $248 In stock
10 mg $398 In stock
25 mg $598 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.
Umibecestat (CNP520) reduced significantly Aβ levels in mice and rats in acute and chronic treatment regimens without any side effects.

Physicochemical Properties

M.Wt 513.801
Formula C19H15ClF7N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-5-fluoropyridin-2-yl)-3-chloro-5-(trifluoromethyl)picolinamide

References

1. Neumann U, et al. EMBO Mol Med. 2018 Sep 17. pii: e9316. doi: 10.15252/emmm.201809316.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: