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Chemical Structure : UoS12258
Catalog No.: PC-35565Not For Human Use, Lab Use Only.
UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6.
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UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6.
UoS12258 displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs.
UoS12258 displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo.
UoS12258 exhibits cognition enhancing properties in several rat behavioural models.
| M.Wt | 334.409 | |
| Formula | C17H19FN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ward SE, et al. J Med Chem. 2010 Aug 12;53(15):5801-12.
2. Ward SE, et al. Br J Pharmacol. 2017 Mar;174(5):370-385.
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