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Uprifosbuvir

Chemical Structure : Uprifosbuvir

CAS No.: 1496551-77-9

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Uprifosbuvir (MK3682;IDX 21437)

Catalog No.: PC-61414Not For Human Use, Lab Use Only.

Uprifosbuvir (MK3682, IDX 21437) is a novel uridine nucleotide analog HCV NS5B polymerase inhibitor for treatment of HCV infection combined with Grazoprevir and Ruzasvir.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Uprifosbuvir (MK3682, IDX 21437) is a novel uridine nucleotide analog HCV NS5B polymerase inhibitor for treatment of HCV infection combined with Grazoprevir and Ruzasvir.

Physicochemical Properties

M.Wt 545.91
Formula C22H29ClN3O9P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Propan-2-yl (2R)-2-{[(R)-({(2R,3R,4R,5R)-4-chloro-5-[2,4-dioxo-3,4dihydropyrimidin-1(2H)-yl]-3-hydroxy-4-methyloxolan-2yl}methoxy)(phenoxy)phosphoryl]amino}propanoate

References

1. Wyles D, et al. Hepatology. 2017 Jul 7. doi: 10.1002/hep.29358.

2. Lawitz E, et al. Lancet Gastroenterol Hepatol. 2017 Aug 9. pii: S2468-1253(17)30163-2.

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