Chemical Structure : Urantide
CAS No.:
669089-53-6
Urantide
Catalog No.: PC-28278Not For Human Use, Lab Use Only.
Urantide is a potent, selective, peptidic urotensin-II receptor (U-II, UT receptor) antagonist, blocks hU-II-induced contractions in rat isolated thoracic aorta with pKb of 8.3.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Urantide is a potent, selective, peptidic urotensin-II receptor (U-II, UT receptor) antagonist, blocks hU-II-induced contractions in rat isolated thoracic aorta with pKb of 8.3.
Urantide is able to modify noradrenaline- or endothelin 1-induced contractile effects.
Urantide displaces [125I]urotensin II from specific binding at hU-II recombinant receptors (UT receptors) transfected into CHO/K1 cells with pKi of 8.3.
Urantide is a competitive, potent (pA2 8.24), and pure antagonist in the rat aorta bioassay.
Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors.
Physicochemical Properties
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M.Wt
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1075.26
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Formula
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C51H66N10O12S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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L-Valine, L-α-aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (2→7)-disulfide
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References
1. Patacchini R, et al. Br J Pharmacol. 2003 Dec;140(7):1155-8.
2. Camarda V, et al. Eur J Pharmacol. 2004 Sep 13;498(1-3):83-6.
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