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Urea transport inhibitor 25a

Chemical Structure : Urea transport inhibitor 25a

CAS No.: 2569547-72-2

Urea transport inhibitor 25a

Catalog No.: PC-26597Not For Human Use, Lab Use Only.

Urea transport inhibitor 25a is a competitive, orally available inhibitor of urea transporters with IC50 of 0.14 μM and 0.48 μM against UT-B in rats and mice, respectively, inhibits both UT-A1 and UT-B.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Urea transport inhibitor 25a is a competitive, orally available inhibitor of urea transporters with IC50 of 0.14 μM and 0.48 μM against UT-B in rats and mice, respectively, inhibits both UT-A1 and UT-B.
25a showed strong inhibitory activity against both UT-B and UT-A1 at 8 uM.

Physicochemical Properties

M.Wt 286.29
Formula C15H14N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide

References

1. Wang S, et al. Eur J Med Chem. 2021 Dec 15;226:113859.

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