Urolithin A is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
Urolithin A prevents the accumulation of dysfunctional mitochondria with age and extends lifespan in C. elegans.
Urolithin A improves exercise capacity in mouse models of age-related decline of muscle function.
Physicochemical Properties
M.Wt
228.2002
Formula
C13H8O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 33 mg/mL
Chemical Name/SMILES
6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy-
References
1. Ryu D, et al. Nat Med. 2016 Aug;22(8):879-88.
2. Tang L, et al. Biochem Biophys Res Commun. 2017 May 6;486(3):774-780.
3. Guada M, et al. J Pharmacol Exp Ther. 2017 Oct;363(1):58-65.
