Usmarapride | 5-HT4 agonist | Probechem Biochemicals

Chemical Structure : Usmarapride

Usmarapride (SUVN-D4010)

Catalog No.: PC-73299Not For Human Use, Lab Use Only.

Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist with EC50of 44 nM.

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Biological Activity

Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist with EC50of 44 nM.
Usmarapride (SUVN-D4010) showed balanced physicochemical-pharmacokinetic properties with robust nonclinical efficacy in cognition models.
Usmarapride (SUVN-D4010) also showed disease-modifying potential, as it increased neuroprotective soluble amyloid precursor protein alpha levels, and dose-dependent target engagement and correlation of efficacy with oral exposures.

Physicochemical Properties

M.Wt	473.530
Formula	C23H31N5O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Nirogi R, et al. J Med Chem. 2021 Aug 12;64(15):10641-10665.

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Usmarapride (SUVN-D4010)

Biological Activity

Physicochemical Properties

References

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