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Chemical Structure : V0162
Catalog No.: PC-61048Not For Human Use, Lab Use Only.
V0162 ((R)-Mequitazine) is a high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21.
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V0162 ((R)-Mequitazine) is a high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21.
V0162 acts an inverse agonist for hM3R-mediated reporter gene activation (pIC50=7.56), with much the same efficacy as atropine, ipratropium and tiotropium.
V0162 antagonizes acetylcholine-mediated contractions in a human bronchial preparation.
| M.Wt | 322.47 | |
| Formula | C20H22N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Devillier P, et al. Respir Res. 2015 Jun 8;16:68.
2. Heusler P, et al. Pharmacol Res. 2015 Oct;100:117-26.
3. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.
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