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Chemical Structure : VA-012
Catalog No.: PC-62010Not For Human Use, Lab Use Only.
VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM.
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VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM.
VA-012 shows no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands.
VA-012 increases the anorectic effect combined with the SSRI sertraline.
VA-012 reduces food intake and body weight gain without causing CNS-related malaise.
| M.Wt | 313.4 | |
| Formula | C21H19N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. García Cárceles J, et al. J Med Chem. 2017 Nov 8. doi: 10.1021/acs.jmedchem.7b00994.
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