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VAL-083

Chemical Structure : VAL-083

CAS No.: 23261-20-3

VAL-083 (Dianhydrodulcitol)

Catalog No.: PC-20967Not For Human Use, Lab Use Only.

VAL-083 (Dianhydrodulcitol) is a small alkylating molecule that induces interstrand DNA crosslinking, induces persistent DNA double-strand breaks (DSB) and cell-cycle arrest in a p53-dependent or p53-independent manner.

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Biological Activity

VAL-083 (Dianhydrodulcitol) is a small alkylating molecule that induces interstrand DNA crosslinking, induces persistent DNA double-strand breaks (DSB) and cell-cycle arrest in a p53-dependent or p53-independent manner.

Physicochemical Properties

M.Wt 146.14
Formula C6H10O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O[C@H]([C@H](O)[C@@]1(CO1)[H])[C@]2(CO2)[H]

References

1. Jiménez-Alcázar M, et al. Mol Cancer Ther. 2021 Jun;20(6):1029-1038.

2. Golebiewska A, et al. Acta Neuropathol. 2020 Dec;140(6):919-949.

3. Nemeth L, et al. Cancer Chemother Rep 1972;56:593–602.

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