VASH1-VASH2 inibitor LV87

Chemical Structure : VASH1-VASH2 inibitor LV87

Catalog No.: PC-25427Not For Human Use, Lab Use Only.

LV87 is a potent, selective and covalent inhibitor of tubulin detyrosinating enzymes VASH1 and VASH2 with IC50 of 0.01 and 0.06 uM respectively, inhibits tubulin detyrosination.

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Biological Activity

LV87 is a potent, selective and covalent inhibitor of tubulin detyrosinating enzymes VASH1 and VASH2 with IC50 of 0.01 and 0.06 uM respectively, inhibits tubulin detyrosination.

Physicochemical Properties

M.Wt	646.70
Formula	C34H38N4O9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(4-(Benzyloxy)phenyl)-2-((2S,3S)-3-(((S)-6-(hydroxyamino)-1,6-dioxo-1-(phenethylamino)hexan-2-yl)carbamoyl)oxirane-2-carboxamido)propanoic Acid

References

1. Feral A, et al. J Med Chem. 2025 Aug 25. doi: 10.1021/acs.jmedchem.5c00980.

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