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Chemical Structure : VB-82252
Catalog No.: PC-35006Not For Human Use, Lab Use Only.
VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM).
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VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM).
VB-82252 protects CHO-K1 cells against challenge with purified TcdA (IC50 = 5.0 uM) or TcdB (IC50=0.25 uM).
VB-82252 prevents inflammation in murine intrarectal toxin challenge model, reduces weight loss and gut inflammation during acute disease in murine model of recurrent Clostridium difficile infection (CDI), demonstrates efficacy similar to that of vancomycin.
| M.Wt | 614.406 | |
| Formula | C29H20Cl2F3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stroke IL, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00107-18.
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