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Chemical Structure : VB124
CAS No.: 2230186-18-0
Catalog No.: PC-38048Not For Human Use, Lab Use Only.
VB124 is a selective, highly potent MCT4 inhibitor, blocks lactate import (IC50 =8.6 nM) and export (IC50=19 nM) in MDA-MB-231 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VB124 is a selective, highly potent MCT4 inhibitor, blocks lactate import (IC50 =8.6 nM) and export (IC50=19 nM) in MDA-MB-231 cells.
VB124 is highly selective for MCT4 over MCT1, showing very little MCT1 inhibitory activity (IC50=24 μM) in MCT1-expressing BT20 cells.
VB124 prevents and reverses hypertrophy in cardiomyocytes, prevents the increased flux from glucose into pyruvate and intra- and extracellular lactate observed in PE- and ISO-treated cardiomyocytes.
VB124 replenishes mitochondrial pyruvate flux, improves mitochondrial membrane potential and mitigates cytosolic ROS.
VB124 prevents cardiac hypertrophy in mice.
| M.Wt | 426.89 | |
| Formula | C23H23ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((1-(2-chlorophenyl)-5-(3-cyclopropoxyphenyl)-1H-pyrazol-3-yl)methoxy)-2-methylpropanoic acid |
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1. Cluntun AA, et al. Cell Metab. 2021 Mar 2;33(3):629-648.e10.
2. Fang Y, et al. Hepatology. 2022 Jan 19.
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