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VB253

Chemical Structure : VB253

CAS No.: 2230187-60-5

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VB253 (VB-253)

Catalog No.: PC-28338Not For Human Use, Lab Use Only.

VB253 is a potent small molecule inhibitor of monocarboxylate transporter 4 (MCT4, lactate transporter SLC16A3), enhances oxidative phosphorylation, reduces oxidative stress, and decreases glucose metabolite uptake, ameliorates pulmonary fibrosis in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VB253 is a potent small molecule inhibitor of monocarboxylate transporter 4 (MCT4, lactate transporter SLC16A3), enhances oxidative phosphorylation, reduces oxidative stress, and decreases glucose metabolite uptake, ameliorates pulmonary fibrosis in vivo.

Physicochemical Properties

M.Wt 461.56
Formula C27H31N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((1-(2-(azetidin-1-yl)phenyl)-5-(3-cyclobutoxyphenyl)-1H-pyrazol-3-yl)methoxy)-2-methylpropanoic acid

References

1. Patent US20180162822 A1 2018-06-14.

2. Ziehr DR, et al. Sci Transl Med. 2026 May 6;18(848):eads2673.

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