Catalog No.: PC-38802Not For Human Use, Lab Use Only.
VBIT-12 is a selective inhibitor of the mitochondria gate-keeper protein, voltage-dependent-anion channel 1 (VDAC1), directly interacting with purified VDAC1 and reducing the channel conductance.
VBIT-12 is a selective inhibitor of the mitochondria gate-keeper protein, voltage-dependent-anion channel 1 (VDAC1), directly interacting with purified VDAC1 and reducing the channel conductance.
VBIT-12 treatment of cultured colon cells inhibited the DSS-induced VDAC1 overexpression, oligomerization, and apoptosis.
VBIT-12 suppressed weight loss, diarrhea, rectal bleeding, pro-inflammatory cytokine production, crypt and epithelial cell damage, and focal inflammation in DSS-treated mice
