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Chemical Structure : VBIT-12
CAS No.: 2089227-65-4
Catalog No.: PC-38802Not For Human Use, Lab Use Only.
VBIT-12 is a selective inhibitor of the mitochondria gate-keeper protein, voltage-dependent-anion channel 1 (VDAC1), directly interacting with purified VDAC1 and reducing the channel conductance.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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VBIT-12 is a selective inhibitor of the mitochondria gate-keeper protein, voltage-dependent-anion channel 1 (VDAC1), directly interacting with purified VDAC1 and reducing the channel conductance.
VBIT-12 treatment of cultured colon cells inhibited the DSS-induced VDAC1 overexpression, oligomerization, and apoptosis.
VBIT-12 suppressed weight loss, diarrhea, rectal bleeding, pro-inflammatory cytokine production, crypt and epithelial cell damage, and focal inflammation in DSS-treated mice
| M.Wt | 417.509 | |
| Formula | C25H27N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(1-(naphthalen-1-ylmethyl)-4-(phenylamino)piperidine-4-carbonyl)glycine |
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1. Verma A, et al. Mol Ther. 2022 Feb 2;30(2):726-744.
2. Niu B, et al. Cell Biol Toxicol. 2021 Aug 17. doi: 10.1007/s10565-021-09624-x.
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