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VBY-825

Chemical Structure : VBY-825

CAS No.: 1310340-58-9

VBY-825 (VBY825)

Catalog No.: PC-21763Not For Human Use, Lab Use Only.

VBY-825 is an reversible cathepsin inhibitor of cathepsins B, L, S and V.with Ki values of 130/250/250/330/2.3/4.7 nM (cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VBY-825 is an reversible cathepsin inhibitor of cathepsins B, L, S and V.with Ki values of 130/250/250/330/2.3/4.7 nM (cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F).
VBY-825 significantly decreases tumor burden and tumor number in pre-clinical model of pancreatic islet cancer.
VBY-825 antagonizes  SARS coronavirus 2 (SARS-CoV-2) viral replication.

Physicochemical Properties

M.Wt 535.55
Formula C23H29F4N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-Cyclopropyl-3-((R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanamido)-2-oxopentanamide

References

1. Riva L, et al. bioRxiv. 2020 Apr 17:2020.04.16.044016.

2. Riva L, et al. Nature. 2020 Oct;586(7827):113-119.

3. Elie BT, et al. Biochimie. 2010 Nov;92(11):1618-24.

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