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Chemical Structure : VBY-825
CAS No.: 1310340-58-9
Catalog No.: PC-21763Not For Human Use, Lab Use Only.
VBY-825 is an reversible cathepsin inhibitor of cathepsins B, L, S and V.with Ki values of 130/250/250/330/2.3/4.7 nM (cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F).
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|---|---|---|---|
| 2 mg | $358 | In stock | |
| 5 mg | $598 | In stock | |
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| 25 mg | Get quote | ||
| 100 mg | Get quote |
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VBY-825 is an reversible cathepsin inhibitor of cathepsins B, L, S and V.with Ki values of 130/250/250/330/2.3/4.7 nM (cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F).
VBY-825 significantly decreases tumor burden and tumor number in pre-clinical model of pancreatic islet cancer.
VBY-825 antagonizes SARS coronavirus 2 (SARS-CoV-2) viral replication.
| M.Wt | 535.55 | |
| Formula | C23H29F4N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-Cyclopropyl-3-((R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanamido)-2-oxopentanamide |
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1. Riva L, et al. bioRxiv. 2020 Apr 17:2020.04.16.044016.
2. Riva L, et al. Nature. 2020 Oct;586(7827):113-119.
3. Elie BT, et al. Biochimie. 2010 Nov;92(11):1618-24.
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