VD11-4-2

Chemical Structure : VD11-4-2

Catalog No.: PC-23741Not For Human Use, Lab Use Only.

VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes.

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Biological Activity

VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes.
VD11-4-2 exhibits strongest inhibition of recombinant human CA IX's catalytic domain in human cells achieved an affinity of 50 pM.

Physicochemical Properties

M.Wt	444.48
Formula	C16H23F3N2O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(cyclooctylamino)-2,5,6-trifluoro-4-((2-hydroxyethyl)sulfonyl)benzenesulfonamide

References

1. Kazokaitė J, et al. J Enzyme Inhib Med Chem. 2016;31(sup4):38-44.

2. Dudutienė, V. et al. Journal of Medicinal Chemistry, 57, 9435–9446.

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VD11-4-2

Biological Activity

Physicochemical Properties

References

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