VDAC inhibitor SC18

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Chemical Structure : VDAC inhibitor SC18

Catalog No.: PC-38524Not For Human Use, Lab Use Only.

VDAC inhibitor SC18 is a specific small molecule targeting the NADH-binding pocket of voltage dependent anion channels (VDAC), decreases mitochondrial membrane potential ΔΨm in HepG2 cells (EC50=25 uM), modulates mitochondrial metabolism in cancer cells, inhibit cell proliferation and induce cell death.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VDAC inhibitor SC18 is a specific small molecule targeting the NADH-binding pocket of voltage dependent anion channels (VDAC), decreases mitochondrial membrane potential ΔΨm in HepG2 cells (EC50=25 uM), modulates mitochondrial metabolism in cancer cells, inhibit cell proliferation and induce cell death.

Physicochemical Properties

M.Wt	385.683
Formula	C15H7ClF3N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-chloro-5-(trifluoromethyl)phenyl)-6-nitroquinazoline-2,4(1H,3H)-dione

References

1. Heslop KA, et al. Biomed Pharmacother. 2022 Apr 18;150:112928.

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