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VE-821

Chemical Structure : VE-821

CAS No.: 1232410-49-9

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VE-821 (VE821;VE 821)

Catalog No.: PC-44042Not For Human Use, Lab Use Only.

VE-821 (VE821) is a potent, selective and ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM, respectively.

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5 mg $58 In stock
10 mg $88 In stock
25 mg $128 In stock
50 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VE-821 (VE821) is a potent, selective and ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM, respectively.
VE-821 shows excellent selectivity for ATR over the related PIKKs ATM, DNA-PK, mTOR and PI3K.

Physicochemical Properties

M.Wt 368.4096
Formula C18H16N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-

References

1. Reaper PM, et al. Nat Chem Biol, 2011, 7(7), 428-430.

2. Charrier JD, et al. J Med Chem, 2011, 54(7), 2320-2330.

3. Prevo R, et al. Cancer Biol Ther. 2012 Sep;13(11):1072-81.

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