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Chemical Structure : VEL-0230
Catalog No.: PC-62965Not For Human Use, Lab Use Only.
VEL-0230 (NC-2300) is a potent, selective cysteine Cathepsins inhibitor with IC50 of 284, 34.5 and 186 nM for Cat B, K and S, respectively.
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VEL-0230 (NC-2300) is a potent, selective cysteine Cathepsins inhibitor with IC50 of 284, 34.5 and 186 nM for Cat B, K and S, respectively.
VEL-0230 (NC-2300) does not inhibit other proteinases such as MMPs (IC50>1 uM).
VEL-0230 (NC-2300) prevents the progression of cerebral aneurysms by inhibiting ECM degradation in aneurysmal walls caused by cystein cathepsins.
VEL-0230 (NC-2300) significantly ameliorates PMA-induced psoriasis-like lesions in mice, and downregulates the expression of IL-12, IL-23, and Th17 cytokines.
| M.Wt | 309.338 | |
| Formula | C14H24NNaO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Asagiri M, et al. Science. 2008 Feb 1;319(5863):624-7.
2. Aoki T, et al. Stroke. 2008 Sep;39(9):2603-10.
3. Hirai T, et al. J Immunol. 2013 May 1;190(9):4805-11.
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