VERU-111 analogue 13f

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Chemical Structure : VERU-111 analogue 13f

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Catalog No.: PC-35599Not For Human Use, Lab Use Only.

VERU-111 analogue 13f is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities.

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Biological Activity

VERU-111 analogue 13f is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities.
VERU-111 analogue 13f inhibits cell viability of human melanoma cell lines (A375, M14, and RPMI7951) with IC50 of 1-3 nM.
VERU-111 analogue 13f is significantly more potent than VERU-111, exhibits a strong inhibitory effect on tumor growth in vivo.

Physicochemical Properties

M.Wt	373.368
Formula	C21H15N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(1H-indol-3-yl)-1H-imidazol-5-yl)(8-methoxybenzo[b][1,4]dioxin-6-yl)methanone

References

1. Wang Q, et al. J Med Chem. 2018 Aug 30. doi: 10.1021/acs.jmedchem.8b00827.

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