VGSC blocker 1 |CAS: 2230472-55-4 Probechem Biochemicals

Chemical Structure : VGSC blocker 1

VGSC blocker 1 (Nav1.5 inhibitor 1)

Catalog No.: PC-35117Not For Human Use, Lab Use Only.

VGSC blocker 1 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 34.9% at 1 uM.

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Biological Activity

VGSC blocker 1 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 34.9% at 1 uM.
VGSC blocker 1 inhibits cell invasion 0.3% at 1 uM in human breast cancer cell line MDA-MB-231, without affecting the cell viability.

Physicochemical Properties

M.Wt	386.531
Formula	C24H32F2N2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4-bis(4-fluorophenyl)-N-(3-(piperidin-1-yl)propyl)butan-1-amine

References

1. Dutta S, et al. Bioorg Med Chem. 2018 May 15;26(9):2428-2436.

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VGSC blocker 1 (Nav1.5 inhibitor 1)

Biological Activity

Physicochemical Properties

References

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