Chemical Structure : VH4004280
CAS No.:
3064931-48-9
VH4004280
(VH-280)
Catalog No.: PC-25439Not For Human Use, Lab Use Only.
VH4004280 (VH-280) is a highly potent HIV-1 capsid inhibitor with EC50 and EC90 of 0.093 nM and 0.23 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VH4004280 (VH-280) is a highly potent HIV-1 capsid inhibitor with EC50 and EC90 of 0.093 nM and 0.23 nM respectively.
VH4004280 (VH-280) exhibits antiviral activity against additional viral strains with E50 of 0.085-0.48 nM.
VH4004280 (VH-280) inhibits a broad spectrum of HIV-1 isolates, and chimeric viruses derived from sequences of multiple group M subtypes, including subtypes A, B, C, F, G, and CRF01_AE.
VH4004280 (VH-280) also blocks nuclear import, total reverse transcript production, integration, virion assembly, and maturation.
Physicochemical Properties
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M.Wt
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950.24
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Formula
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C41H29ClF9N9O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((S)-1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-7-(6-(trifluoromethyl)pyridin-2-yl)-3,4-dihydroquinazolin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-3-(difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide
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References
1. Wang C, et al. Antimicrob Agents Chemother. 2025 Sep 3:e0030925.
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