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Chemical Structure : VI-116
Catalog No.: PC-38691Not For Human Use, Lab Use Only.
VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.
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VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.
VI-116 potently blocked endogenous VRAC activity in PC3, HT29 and HeLa cells in a dose-dependent manner.
VI-116 had no effect on intracellular calcium signaling up to 10 μM, which completely inhibited VRAC, and showed high selectivity for VRAC compared to ANO1 and ANO2.
VI-116 showed minimal effect on hERG K+ channel activity up to 10 μM.
| M.Wt | 458.422 | |
| Formula | C26H18O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dongkyu Jeon, et al. Int J Mol Sci. 2022 May 5;23(9):5168.
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