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VI-116

Chemical Structure : VI-116

CAS No.: 1380411-59-5

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VI-116 (VI116)

Catalog No.: PC-38691Not For Human Use, Lab Use Only.

VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.
    VI-116 potently blocked endogenous VRAC activity in PC3, HT29 and HeLa cells in a dose-dependent manner.
    VI-116 had no effect on intracellular calcium signaling up to 10 μM, which completely inhibited VRAC, and showed high selectivity for VRAC compared to ANO1 and ANO2.
    VI-116 showed minimal effect on hERG K+ channel activity up to 10 μM.

    Physicochemical Properties

    M.Wt 458.422
    Formula C26H18O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,3'-((2-hydroxy-3-methoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

    References

    1. Dongkyu Jeon, et al. Int J Mol Sci. 2022 May 5;23(9):5168.

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