Catalog No.: PC-38030Not For Human Use, Lab Use Only.
VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.
VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.
VK2809 decreases hepatic triglyceride levels in GSD Ia mice through its simultaneous restoration of autophagy, mitochondrial biogenesis, and β-oxidation of fatty acids.
VK2809 (MB07811) is converted to MB07344 in liver microsomes.
VK2809 showed potent lipid lowering activity in the CFR (ED(50) 0.4 mg/kg, po) and good oral bioavailability (40%, rat).
