Chemical Structure : VKT-17-P4-23
CAS No.:
2411865-57-9
VKT-17-P4-23
Catalog No.: PC-28358Not For Human Use, Lab Use Only.
VKT-17-P4-23 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 72 nM, has MIC50 of 16 ug/mL against S. Typhimurium.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VKT-17-P4-23 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 72 nM, has MIC50 of 16 ug/mL against S. Typhimurium.
VKT-17-P4-23 has microscale thermophoresis (MST) with a dissociation constant (Kd) of 124 μM, does not bind GreA and GreB.
VKT-17-P4-23 exerts antimicrobial activity, reduces the formation of intracellularly selected populations of Salmonella persistent cells.
VKT-17-P4-23 protects mice from the liver toxicity associated with Salmonella infection.
VKT-17-P4-23 exhibits antibiotic activity against Salmonella in gastrointestinal and systemic murine models of infection.
Physicochemical Properties
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M.Wt
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244.30
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Formula
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C13H16N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-phenylbutyl)-1H-1,2,4-triazole-3-carboxamide
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References
1. Kim JS, et al. Sci Adv. 2026 Mar 20;12(12):eaea6832.
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