VNI-5168 | HSV-1 UL12 inhibitor | Probechem Biochemicals

Chemical Structure : VNI-5168

VNI-5168 (VNI5168)

Catalog No.: PC-27117Not For Human Use, Lab Use Only.

VNI-5168 is a potent, small molecule inhibitor of HSV-1 UL12 alkaline nuclease with IC50 of 1.2 uM and MST Kd value of 0.145 uM, shows broad anti-HSV activity.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

VNI-5168 is a potent, small molecule inhibitor of HSV-1 UL12 alkaline nuclease with IC50 of 0.63 uM and MST Kd value of 0.145 uM, shows broad anti-HSV activity.
VNI-5168 exhibited antiviral activity against HSV-1 with EC50 of 0.42 uM.
VNI-5168 is also effective against alkaline nucleases from the b-HHV HCMV (UL98) and the g-HHV KSHV (SOX).
VNI-5168 also shows significant inhibition of HCMV, consistent with their potency against the UL98 enzyme.
VNI-5168 demonstrates antiviral activity against HSV-1 and HCMV in cell culture.

Physicochemical Properties

M.Wt	615.32
Formula	C24H22BrCl2N3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromophenyl)-1-((1-((2,3-dichlorophenyl)sulfonyl)piperidin-4-yl)methyl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxamide

References

1. Sharma N, et al. bioRxiv [Preprint]. 2026 Jun 5:2026.06.03.729350.

VNI-5168 (VNI5168)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.