Chemical Structure : VNT-101
CAS No.:
2894060-67-2
VNT-101
(VNT101)
Catalog No.: PC-25217Not For Human Use, Lab Use Only.
VNT-101 (VNT101) is a potent influenza A virus (IAV) inhibitor disrupting of nucleoprotein (NP)-NP protein-protein interaction (PPI), targets nucleoprotein (NP) subunit of the viral RNP replication complex, has cellular EC50 of 5 nM in H1N1 CPE assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VNT-101 (VNT101) is a potent influenza A virus (IAV) inhibitor disrupting of nucleoprotein (NP)-NP protein-protein interaction (PPI), targets nucleoprotein (NP) subunit of the viral RNP replication complex, has cellular EC50 of 5 nM in H1N1 CPE assays.
VNT-101 exhibited attractive pharmacokinetics in rats and dogs, and a favorable preclinical safety profile.
VNT-101 demonstrated robust antiviral activity in rodent models of influenza infection.
Physicochemical Properties
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M.Wt
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456.42
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Formula
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C21H23F3N2O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(4-(((2S,6S)-6-(Methoxymethyl)-6-methyl-1,4-dioxan-2-yl)methoxy)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide
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References
1. Taft BR, et al. J Med Chem. 2025 Jul 23. doi: 10.1021/acs.jmedchem.5c01233.
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