Chemical Structure : VP-14637
CAS No.:
235106-62-4
VP-14637
(MDT-637;MDT637;VP14637)
Catalog No.: PC-63268Not For Human Use, Lab Use Only.
VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function; does not block RSV adsorption but inhibits RSV-induced cell-cell fusion and binds specifically to RSV-infected cells, specifically interacts with the RSV fusion protein expressed by a T7 vaccinia virus system; the F proteins containing the resistance mutations exhibits greatly reduced binding of VP-14637.
RSV Infection
Discontinued
Physicochemical Properties
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M.Wt
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510.5
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Formula
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C25H22N10O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,2'-[(4-Hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]phenol]
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References
1. Kim YI, et al. Influenza Other Respir Viruses. 2017 Nov;11(6):525-530.
2. Douglas JL, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6.
3. Douglas JL, et al. J Virol. 2003 May;77(9):5054-64.
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