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Chemical Structure : VP-14637
Catalog No.: PC-63268Not For Human Use, Lab Use Only.
VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function.
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VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function; does not block RSV adsorption but inhibits RSV-induced cell-cell fusion and binds specifically to RSV-infected cells, specifically interacts with the RSV fusion protein expressed by a T7 vaccinia virus system; the F proteins containing the resistance mutations exhibits greatly reduced binding of VP-14637.
RSV Infection
Discontinued
| M.Wt | 510.5 | |
| Formula | C25H22N10O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim YI, et al. Influenza Other Respir Viruses. 2017 Nov;11(6):525-530.
2. Douglas JL, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6.
3. Douglas JL, et al. J Virol. 2003 May;77(9):5054-64.
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