VRK1/CK1-IN-1

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Chemical Structure : VRK1/CK1-IN-1

Catalog No.: PC-26318Not For Human Use, Lab Use Only.

VRK1/CK1-IN-1 is a potent, dual inhibitor of Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) with Ki of 37.9 nM for VRK1, and IC50 of 17 nM and 15 nM for CK1δ and CK1ε, mimics the cellular outcomes of VRK1 depletion.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	416.39
Formula	C19H18F2N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((3,5-Difluoro-4-hydroxyphenyl)amino)-7,8-dimethyl-5-((3-methylisoxazol-5-yl)methyl)-7,8-dihydropteridin-6(5H)-one

References

1. Fernando H de Souza Gama, et al. J Med Chem. 2024 Jun 13;67(11):8609-8629.

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VRK1/CK1-IN-1

Biological Activity

Physicochemical Properties

References

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