Catalog No.: PC-26277Not For Human Use, Lab Use Only.
VT3989 is a first-in-class, orally bioavailable, selective and potent inhibitor of YAP/TEAD inhibitor, inhibits TEAD autopalmitoylation and disrupts YAP transcriptional activity.
VT3989 is a first-in-class, orally bioavailable, selective and potent inhibitor of YAP/TEAD inhibitor, inhibits TEAD autopalmitoylation and disrupts YAP transcriptional activity. VT3989 effectively binds to all four TEAD paralogs (TEAD1-TEAD4). VT3989 strongly blocks palmitoylation of TEAD1 and TEAD3, also inhibits palmitoylation of TEAD2 and TEAD4. VT3989 potently inhibit the proliferation of NF2-deficient (NCI-H226, GI50=9 nM) and NF2-mutated (NCI-H2052, GI50=9 nM) and NCI-H2373) cell lines but not NF2 wild-type, Merlin-positive cell lines. VT3989 blocks NCI-H226 NF2-deficient xenograE tumor growth in mice.
