VTD227 | HIV-1 Vpr inhibitor | Probechem Biochemicals

Chemical Structure : VTD227

VTD227 (VTD-227, VTD 227)

Catalog No.: PC-47033Not For Human Use, Lab Use Only.

VTD227 is a small molecule Vpr-targeting HIV-1 inhibitor, directly binds to Vpr with Kd of 8.8 uM, inhibits HIV-1 replication in monocyte-derived macrophages (MDM) with IC50 of 0.78 uM.

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Biological Activity

VTD227 is a small molecule Vpr-targeting HIV-1 inhibitor, directly binds to Vpr with Kd of 8.8 uM, inhibits HIV-1 replication in monocyte-derived macrophages (MDM) with IC50 of 0.78 uM.

Physicochemical Properties

M.Wt	329.356
Formula	C17H19N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-((2-hydroxynaphthalen-1-yl)methylene)hydrazinyl)-N-(3-methoxypropyl)-2-oxoacetamide

References

1. Hirotaka Sato, et al. Viruses. 2022 Jun 16;14(6):1321.

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VTD227 (VTD-227, VTD 227)

Biological Activity

Physicochemical Properties

References

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