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VTD227

Chemical Structure : VTD227

CAS No.: 330858-64-5

VTD227 (VTD-227, VTD 227)

Catalog No.: PC-47033Not For Human Use, Lab Use Only.

VTD227 is a small molecule Vpr-targeting HIV-1 inhibitor, directly binds to Vpr with Kd of 8.8 uM, inhibits HIV-1 replication in monocyte-derived macrophages (MDM) with IC50 of 0.78 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VTD227 is a small molecule Vpr-targeting HIV-1 inhibitor, directly binds to Vpr with Kd of 8.8 uM, inhibits HIV-1 replication in monocyte-derived macrophages (MDM) with IC50 of 0.78 uM.

    Physicochemical Properties

    M.Wt 329.356
    Formula C17H19N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-2-(2-((2-hydroxynaphthalen-1-yl)methylene)hydrazinyl)-N-(3-methoxypropyl)-2-oxoacetamide

    References

    1. Hirotaka Sato, et al. Viruses. 2022 Jun 16;14(6):1321.

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