You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Renin-VTP-27999
VTP-27999

Chemical Structure : VTP-27999

CAS No.: 942142-51-0

VTP-27999 (VTP27999;VTP 27999)

Catalog No.: PC-45864Not For Human Use, Lab Use Only.

A potent, highly selective renin inhibitor with IC50 of 0.47 nM.

Packing Price Stock Quantity
10 mg $528 In stock
50 mg $1100 In stock
100 mg $1760 In stock

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, highly selective renin inhibitor with IC50 of 0.47 nM; displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4; demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.

Hypertension

Phase 1 Clinical

Physicochemical Properties

M.Wt 525.0806
Formula C26H41ClN4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester

References

1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.

2. Krop M, et al. Hypertension. 2013 May;61(5):1075-82.

3. Balcarek J, et al. Hypertension. 2014 May;63(5):942-50.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: