VTP-27999 TFA | Renin inhibitor | Probechem Biochemicals

Chemical Structure : VTP-27999 TFA

CAS No.: 1013937-63-7

VTP-27999 TFA (VTP27999 TFA, VTP 27999)

Catalog No.: PC-45865Not For Human Use, Lab Use Only.

VTP-27999 TFA is a potent, highly selective renin inhibitor with IC50 of 0.47 nM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

VTP-27999 TFA is a potent, highly selective renin inhibitor with IC50 of 0.47 nM.
VTP-27999 displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4.
VTP-27999 demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.

Physicochemical Properties

M.Wt	639.1039
Formula	C28H42ClF3N4O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, 2,2,2-trifluoroacetate (1:1)

References

1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.

2. Krop M, et al. Hypertension. 2013 May;61(5):1075-82.

3. Balcarek J, et al. Hypertension. 2014 May;63(5):942-50.

VTP-27999 TFA (VTP27999 TFA, VTP 27999)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.